RIPK1-dependent apoptosis bypasses pathogen blockade of innate signaling to promote immune defense. Peterson et al. J. Exp. Med. 2017. View PDF here.
Cell-intrinsic TNF collaborates with TRIF signaling to promote Yersinia-induced apoptosis. Peterson et al. J. Immunol. 2016. View PDF here.
Activity of Uncleaved Caspase-8 Controls Anti-bacterial Immune Defense and TLR-induced cytokine production independent of Cell Death. Philip et al. PLoS Pathog. 2016. View PDF here.
Inflammasome Activation in Response to the Yersinia Type III Secretion System Requires Hyperinjection of Translocon Proteins YopB and YopD. Zwack et al. mBio 2015. View PDF here.
Caspase-8 mediates caspase-1 processing and innate immune defense in response to bacterial blockade of NF-kB and MAPK signaling. Philip et al. PNAS 2014. View PDF here.
Oxidative metabolism enables Salmonella evasion of the NLRP3 inflammasome. Wynosky-Dolfi et al. JEM 2014. View PDF here.
Caspase-11 activation in response to bacterial secretion systems that access the host cytosol. Casson et al. PLoS Pathogens. 2013. View PDF here.
A Yersinia Effector Protein Promotes Virulence by Preventing Inflammasome Recognition of the Type III Secretion System. Brodsky et al. Cell Host Microbe 2010. View PDF here.
Reduced Secretion of YopJ by Yersinia Limits In Vivo Cell Death but Enhances Bacterial Virulence. Brodsky and Medzhitov. PLoS Pathogens 2008. View PDF here.
Mig-14 is an inner membrane-associated protein that promotes Salmonella typhimurium resistance to CRAMP, survival within activated macrophages and persistent infection. Brodsky et al. Molecular Microbiology 2005. View PDF here.
mig-14 Is a Salmonella Gene That Plays a Role in Bacterial Resistance to Antimicrobial Peptides. Brodsky et al. Journal of Bacteriology 2002. View PDF here.
Activation and Evasion of Inflammasomes by Yersinia. Naomi Philip, Erin Zwack and Igor Brodsky. Current Topics in Immunology 2016. View PDF here.
The inflammasome: Learning from bacterial evasion strategies. Sunny Shin and Igor Brodsky. Seminars in Immunology 2015. View PDF here.
Targeting of immune signalling networks by bacterial pathogens. Igor Brodsky and Ruslan Medzhitov. Nature Cell Biology 2009. View PDF here.
NLR-mediated control of inflammasome assembly in the host response against bacterial pathogens. Igor Brodsky and Denise Monack. Seminars in Immunology 2009. View PDF here.